Custom Peptides
Cayman Chemical ndocromIlsodIum salt 10mg
A mast cell stabilizer; inhibits IgE-induced histamine release from MC/3T3 cells preincubated with IL-2 at 10 µM; prevents EArly- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin; prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis at 2 mg/kg
Cayman Chemical -trns-GK563 10mg
A GVIA iPLA2 inhibitor (IC50 = 1 nM); selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM); inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells at 1 and 10 μM
Cayman Chemical AcetamIprId 10mg
A neonicotinoid insecticide; an agonist of insect nAChRs; activates nAChRs containing N. lugens α1 and rat β2 subunits (EC50 = 67 µM in X. laevis oocytes); leads to sexual and aggressive behaviors in adult male offspring after administration to pregnant mice (1 mg/kg); decreases anxiety-like behavior of adult male offspring in the light-dark transition test (1 and 10 mg/kg)
Cayman Chemical Rubmaln 10mg
A naphthohydroquinone with diverse biological activities; inhibits the growth of E. coli and S. aureus in a disc assay at 100 μg per disc; scavenges DPPH free radicals in a cell-free assay (IC50 = 0.7 μM); inhibits ACAT1 and ACAT2 (IC50s = 80 and 22 μM, respectively) and cholesterol ester synthesis (IC50 = 18 μM) in murine macrophages; increases BMP2-induced osteoblastic differentiation of C2C12 mesenchymal progenitor cells; enhances skeletal development in zebrafish larvae; inhibits TNF-α-induced NF-κB reporter gene expression and nuclear translocation of p65 and potentiates TNF-α-induced apoptosis in HeLa cells; reduces tumor growth in a HeLa mouse xenograft model at 25 and 75 mg/kg
Cayman Chemical PAR41-6humn 10mg
A peptide agonist of PAR4; activates PAR4 and the cleavage site mutant PAR4R47A at 500 µM; induces platelet aggregation of isolated washed human platelets at 1 mM but does not affect clotting time ex vivo
Cayman Chemical PaclItaxel octadecndIoate 10mg
A prodrug form of paclitaxel; comprised of paclitaxel conjugated to 1,18-octadecanedioic acid; does not promote tubulin polymerization in vitro at 10 μM; cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50 = 12, 2.48, and 8.62 nM, respectively) as a 5:1 mixture with HSA; mixture with HSA reduces tumor growth and increases survival in an HT-1080 mouse xenograft model in a dose-dependent manner
Cayman Chemical 3a-AmInocholestn 10mg
An inhibitor of SHP-1 (IC50 = ~2.5 µM); selective for SHP-1 over SHP-2 and PTEN (IC50s = >20 µM); induces hyperactivation of SYK in patient-derived Ph+ ALL cells; reduces leukemia burden and increases survival in a tyrosine kinase inhibitor-resistant patient-derived Ph+ ALL mouse xenograft model at 50 mg/kg; reduces cell viability of OPM2 cells in a concentration-dependent manner and of RPMI8226 cells at ≥12.5 µM; halts the cell cycle at the G0/G1 or G2/M stages in the highly proliferative OPM2 or less proliferative RPMI8226 cell lines, respectively; induces apoptosis via activation of caspase-3, caspase-9, and PARP in OPM2 cells but not in RPMI8226 cells
Cayman Chemical 1 2DIpalmItoyl3Stearoylra 10mg
A triacylglycerol; has been found in ostrich and emu oils as well as cow milk fat
Cayman Chemical AzasetronhydrochlorIde 10mg
An orally bioavailable 5-HT3 antagonist (Ki = 2.9 nM); selective for 5-HT3 over 5-HT1A and 5-HT2 (IC50 = >10 μM for both), as well as D1, D2, α1-, and α2-adrenergic receptors (IC50s = >10 μM); binds to H1 receptors (IC50 = 4.4 μM); inhibits 5-HT-induced contractions in isolated guinea pig ileum (pA2 = 7.04) and isolated rabbit heart (pA2 = 10.06); inhibits cisplatin-induced emesis in dogs and doxorubicin/cyclophosphamide-induced emesis in ferrets at 1 mg/kg
Cayman Chemical ElagolIxsodIum salt 10mg
An antagonist of GnRHR (Ki = 0.9 nM in a radioligand binding assay); selective for GnRHR over CYP3A4 (IC50 = 56 μM) as well as a panel of 100 receptors, ion channels, enzymes, and transporters (IC50s = >10 μM); inhibits GnRH-induced inositol phosphate production in RBL-1 cells expressing human GnRHR (IC50 = 1.5 nM); suppresses production of luteinizing hormone in castrated male cynomolgus macaques at 30 mg/kg
Cayman Chemical IACS-010759 10mg
An orally bioavailable inhibitor of mitochondrial complex I; inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I at 60 nM; reduces basal and spare respiratory capacities and increases glycolytic flux in primary CLL cells at 100 nM; induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose; induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model when administered at doses of 5 and 10 mg/kg
Cayman Chemical LnreotIdeacetate 10mg
A somatostatin receptor agonist with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100nM, respectively); inhibits the release of growth hormone from patient-derived pituitary adenoma cells in vitro when used at a concentration of 100 nM; inhibits tumor growth in SCLC mouse xenograft models when administered at a dose of 250 UG, twice daily